منابع مشابه
Pharmacologic Effects of Marijuana
Part of the uncertainty is generated by the bias of those occupying the poles of thought that must be repeatedly referred to: the dominant feeling that marijuana is a frighteningly dangerous drug in no way comparable to any accepted social drug, and the often equally emotional claim by groups of increasing size that it is a purely beneficent drug in no way comparable to any acceptable social drug.
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In contrast to acquired resistance to targeted therapeutics via genomic changes, adaptive resistance in cancer involves rapid cellular reprogramming at a nongenomic level. In triple negative breast cancer (TNBC) we have recently described robust transcriptional adaptation to MEK inhibition (MEKi) by the FDA-approved MEK inhibitor, trametinib, in both TNBC patients and preclinical models [1]. Th...
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Capping of membrane Ig was studied in lymphocytes treated with agents that interfere with adenosine metabolism. Treatment of murine or human B cells with combinations of coformycin, an inhibitor of adenosine deaminase, homocysteine, and adenosine impaired Ig capping. Inhibition of capping was also produced by 3-deazaadenosine, a specific inhibitor of adenosylhomocysteine hydrolase. The inhibito...
متن کاملDrug metabolism and hepatotoxicity.
Drug metabolism in the 1960s At the time the Liver Unit was established in 1966, interest in the study of drug metabolism was growing, stimulated largely by the pharmaceutical industry, and the legislative requirements imposed upon it. It represented a remarkable change from the situation a few years previously when'. . . the study ofthe metabolism of foreign compounds was not a popular one; bi...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1985
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)63280-4